Corpus ID: 12095098

Synthetic alpha-subunit peptides stimulate testosterone production in vitro by rat Leydig cells.

@article{Erickson1990SyntheticAP,
  title={Synthetic alpha-subunit peptides stimulate testosterone production in vitro by rat Leydig cells.},
  author={Lisa D. Erickson and Stefano Rizza and Elizabeth R. Bergert and Mary Cristine Charlesworth and Daniel J. Mccormick and Robert J. Ryan},
  journal={Endocrinology},
  year={1990},
  volume={126 5},
  pages={
          2555-60
        }
}
  • Lisa D. Erickson, Stefano Rizza, +3 authors Robert J. Ryan
  • Published in Endocrinology 1990
  • Medicine
  • The glycoprotein hormones (LH, hCG, FSH, and TSH) have a common 92-amino acid alpha-subunit which is noncovalently linked to a hormone-specific beta-subunit. Synthetic peptides of the alpha-subunit have been shown to inhibit binding of [125I]iodo-hCG to rat ovarian membrane and [125I]iodo-TSH to human thyroid membrane preparations. Synthetic overlapping peptides of the alpha-subunit of hCG were prepared by solid phase techniques and tested in a standard in vitro rat Leydig cell bioassay. Three… CONTINUE READING

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