Synthetic Plasmodium-Like Hemozoin Activates the Immune Response: A Morphology - Function Study

@inproceedings{Jaramillo2009SyntheticPH,
  title={Synthetic Plasmodium-Like Hemozoin Activates the Immune Response: A Morphology - Function Study},
  author={Maritza Jaramillo and Marie-Jos{\'e}e Bellemare and Caroline Martel and Marina Tiemi Shio and Ana Paulina Contreras and Marianne Godbout and M. Roger and {\'E}ric Gaudreault and Jean Gosselin and David Scott Bohle and Martin S. Olivier},
  booktitle={PloS one},
  year={2009}
}
Increasing evidence points to an important role for hemozoin (HZ), the malaria pigment, in the immunopathology related to this infection. However, there is no consensus as to whether HZ exerts its immunostimulatory activity in absence of other parasite or host components. Contamination of native HZ preparations and the lack of a unified protocol to produce crystals that mimic those of Plasmodium HZ (PHZ) are major technical limitants when performing functional studies with HZ. In fact, the most… CONTINUE READING
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monocytes and peritoneal macrophages

  • MT Shio, SC Eisenbarth, M Savaria, AF Vinet, MJ Bellemare
  • 2009

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