Synthetic Peptides as cGMP-Independent Activators of cGMP-Dependent Protein Kinase Iα.


PKG is a multifaceted signaling molecule and potential pharmaceutical target due to its role in smooth muscle function. A helix identified in the structure of the regulatory domain of PKG Iα suggests a novel architecture of the holoenzyme. In this study, a set of synthetic peptides (S-tides), derived from this helix, was found to bind to and activate PKG I… (More)
DOI: 10.1016/j.chembiol.2015.11.005

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