Synthetic Lethal Screen Identifies NF-κB as a Target for Combination Therapy with Topotecan for patients with Neuroblastoma

  title={Synthetic Lethal Screen Identifies NF-$\kappa$B as a Target for Combination Therapy with Topotecan for patients with Neuroblastoma},
  author={Patricia S. Tsang and A. Cheuk and Q. Chen and Y. Song and Thomas C. Badgett and Jun S. Wei and J. Khan},
  journal={BMC Cancer},
  pages={101 - 101}
BackgroundDespite aggressive multimodal treatments the overall survival of patients with high-risk neuroblastoma remains poor. The aim of this study was to identify novel combination chemotherapy to improve survival rate in patients with high-risk neuroblastoma.MethodsWe took a synthetic lethal approach using a siRNA library targeting 418 apoptosis-related genes and identified genes and pathways whose inhibition synergized with topotecan. Microarray analyses of cells treated with topotecan were… Expand
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