Synthetic Lethal Interactions in Cancer Therapy.


BACKGROUND Silencing of two or more complementary signaling pathways can lead to cell death, while loss of any single genetic function does not show a severe phnotype, this kind of inter action is coined as "synthetic lethality". Nowadays, synthetic lethality has become a widely used anti-cancer strategy. METHOD We reviewed the synthetic lethal… (More)
DOI: 10.2174/1568009616666160426122736


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