Synthetic Lethal Interactions in Cancer Therapy.

Abstract

BACKGROUND Silencing of two or more complementary signaling pathways can lead to cell death, while loss of any single genetic function does not show a severe phnotype, this kind of inter action is coined as "synthetic lethality". Nowadays, synthetic lethality has become a widely used anti-cancer strategy. METHOD We reviewed the synthetic lethal… (More)
DOI: 10.2174/1568009616666160426122736

Topics

  • Presentations referencing similar topics