Synthetic Investigation toward the D‐Ring‐Functionalized Cytotoxic Oleanane‐Type Saponins Pithedulosides D and E

@article{Ge2017SyntheticIT,
  title={Synthetic Investigation toward the D‐Ring‐Functionalized Cytotoxic Oleanane‐Type Saponins Pithedulosides D and E},
  author={Shipin Ge and Yuan-Hong Tu and Jian‐Hui Xia and Jian-Song Sun},
  journal={European Journal of Organic Chemistry},
  year={2017},
  volume={2017},
  pages={3929-3934}
}
Leveraging on the orchestrated application of both Schmidt and Yu glycosylations, the first total syntheses of echinocystic acid saponins, pitheduloside D and E, the two antitumoral and representative D-ring functionalized oleanane-type saponins, were achieved. Benefited from the applied convergent synthetic strategy, the synthetic efficiency regarding the precious echinocystic acid could reach as high as 71% and 76% overall yields through 4 linear steps. 
3 Citations
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