Synthetic Condensed 1,4-naphthoquinone Derivative Shifts Neural Stem Cell Differentiation by Regulating Redox State

@article{Santos2012SyntheticC1,
  title={Synthetic Condensed 1,4-naphthoquinone Derivative Shifts Neural Stem Cell Differentiation by Regulating Redox State},
  author={Daniela M. Santos and Maria de F{\'a}tima Menezes de Almeida Santos and Rui Moreira and Susana Sol{\'a} and Cec{\'i}lia M. P. Rodrigues},
  journal={Molecular Neurobiology},
  year={2012},
  volume={47},
  pages={313-324}
}
Naphthoquinones are bioactive compounds widespread in nature that impact on several cellular pathways, including cell proliferation and survival, by acting as prooxidants and electrophiles. We have previously described the role of the synthetic isoxazole condensed 1,4-naphthoquinone derivative 1a in preventing apoptosis induced by distinct stimuli in several cell models. In addition, apoptosis regulators and executioners may control neural stem cell (NSC) fate, without involving cell death per… CONTINUE READING

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