Synthetic Biology: Regulating Industry Uses of New Biotechnologies

@article{Erickson2011SyntheticBR,
  title={Synthetic Biology: Regulating Industry Uses of New Biotechnologies},
  author={Brent Erickson and Rina Rani Singh and Paul C. Winters},
  journal={Science},
  year={2011},
  volume={333},
  pages={1254 - 1256}
}
In our view, synthetic biology is an extension of the continuum of genetic science that has been used safely for more than 40 years by the biotechnology industry in the development of commercial products. Examples of synthetic biology use by biotechnology companies illustrate the potential to substantially reduce research and development time and to increase speed to market. Improvements in the speed and cost of DNA synthesis are enabling scientists to design modified bacterial chromosomes that… 

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References

SHOWING 1-10 OF 19 REFERENCES

TECHNOLOGY UPDATE: Development of a gas-phase bioprocess for isoprene-monomer production using metabolic pathway engineering

TLDR
A sustainable production system for isoprene is being developed based on microbial fermentation of renewable sugars (BioIsoprene™), with two biosynthetic isoprenoid pathways being optimized towards this end.

Facts, Growth, and Opportunities in Industrial Biotechnology

The revolution in synthetic biology has enabled innovative manufacture of biofuels and the development of biological processes for the manufacture of bulk and fine chemicals. This short review gives

Creation of a Bacterial Cell Controlled by a Chemically Synthesized Genome

TLDR
The design, synthesis, and assembly of the 1.08–mega–base pair Mycoplasma mycoides JCVI-syn1.0 genome starting from digitized genome sequence information and its transplantation into a M. capricolum recipient cell to create new cells that are controlled only by the synthetic chromosome are reported.

Complete Chemical Synthesis, Assembly, and Cloning of a Mycoplasma genitalium Genome

TLDR
The methods described here will be generally useful for constructing large DNA molecules from chemically synthesized pieces and also from combinations of natural and synthetic DNA segments.

Precise Manipulation of Chromosomes in Vivo Enables Genome-Wide Codon Replacement

TLDR
H hierarchical conjugative assembly genome engineering (CAGE) was developed to merge these sets of codon modifications into genomes with 80 precise changes, which demonstrate that these synonymous codon substitutions can be combined into higher-order strains without synthetic lethal effects.

Evolution of Innovation

  • G. Brooke
  • History
    Pharmaceutical Innovation
  • 2003
In 1856, William Henry Perkin was an 18 year-old student at Britain’s Royal College of Chemistry. He was working toward an antimalarial drug that was important to the British Empire as it expanded

Biocatalytic Asymmetric Synthesis of Chiral Amines from Ketones Applied to Sitagliptin Manufacture

TLDR
An efficient biocatalytic process to replace a recently implemented rhodium-catalyzed asymmetric enamine hydrogenation for the large-scale manufacture of the antidiabetic compound sitagliptin is reported, underscoring the maturation of bioc atalysis to enable efficient, economical, and environmentally benign processes for the manufacture of pharmaceuticals.

New Directions: The Ethics of Synthetic Biology and Emerging Technologies (Presidential Commission for the Study of Bioethical Issues

  • 2010

United Nations Office at Geneva, Disarmament: Think Zone for the Seventh Review Conference, www.unog.ch/80256EE600585943/(httpPages)/ 0FF9CBDC43026888C12577B5004E29E4?OpenDocument