Synthetic Biology: Regulating Industry Uses of New Biotechnologies

  title={Synthetic Biology: Regulating Industry Uses of New Biotechnologies},
  author={Brent Erickson and Rina Rani Singh and Paul C. Winters},
  pages={1254 - 1256}
In our view, synthetic biology is an extension of the continuum of genetic science that has been used safely for more than 40 years by the biotechnology industry in the development of commercial products. Examples of synthetic biology use by biotechnology companies illustrate the potential to substantially reduce research and development time and to increase speed to market. Improvements in the speed and cost of DNA synthesis are enabling scientists to design modified bacterial chromosomes that… 

Synthetic Biology Industry: Biosafety Risks to Workers

Synthetic biology involves the design, assembly, synthesis, or manufacture of new genomes, biological pathways, devices, or organisms not found in nature for use in agriculture, bio-manufacturing, health care, energy, and other industrial sectors.

Mammalian designer cells: Engineering principles and biomedical applications

This review discusses the most commonly used techniques to engineer mammalian designer cells; while control elements acting on the transcriptional and translational levels of target gene expression determine the kinetic and dynamic profiles, coupling them to a variety of extracellular stimuli permits their remote control with user‐defined trigger signals.

Synthetic Biology: Solving the Pharmaceutical Industry’s Innovation Problems?

This book chapter review the challenges that the pharmaceutical industry is confronted with, present and analyze examples of applications of synthetic biology in this field, and discuss potential changes to the industry’s intellectual property management that the advent of synthetic Biology might bring about.

Synthetic Biology and Personalized Medicine

  • K. Jain
  • Biology, Chemistry
    Medical Principles and Practice
  • 2012
Of two approaches to synthetic biology, top-down and bottom-up, the latter is more relevant to the development of personalized medicines as it provides more flexibility in constructing a partially synthetic cell from basic building blocks for a desired task.

Synthetic Genomics and Synthetic Biology Applications Between Hopes and Concerns

An overview on recent progress in biomedical and biotechnological applications of synthetic genomics and synthetic biology is provided as well as on arguments and evidence related to their possible benefits, risks and governance implications.

Synthetic Biology of Natural Products.

The current state of the field is discussed, highlighting recent advances and remaining bottlenecks, and global genomic assessments of natural product biosynthetic capacities across large parts of microbial diversity are provided.

Are we doing synthetic biology?

The state of the art on synthetic biology is reviewed and it is concluded that most research projects actually describe an extension of metabolic engineering, and the term synthetic biology should be used more sparingly.

Synthetic biology and occupational risk

ABSTRACT Synthetic biology is an emerging interdisciplinary field of biotechnology that involves applying the principles of engineering and chemical design to biological systems. Biosafety

An overview of synthetic biology

The potential of Synthetic Biology to design new genomes without immediate biological ancestry has raised ontological, political, economic, and ethical concerns based on the possibility that synthetic biology may be intrinsically unethical.

Upstream biomanufacturing of pharmaceutical colchicine

A novel biorhizome approach for biomanufacturing pharmaceutical-grade natural colchicine, a biosynthetic pathway elucidation and its challenges to synthetic biotechnology are emphasized.



TECHNOLOGY UPDATE: Development of a gas-phase bioprocess for isoprene-monomer production using metabolic pathway engineering

A sustainable production system for isoprene is being developed based on microbial fermentation of renewable sugars (BioIsoprene™), with two biosynthetic isoprenoid pathways being optimized towards this end.

Facts, Growth, and Opportunities in Industrial Biotechnology

The revolution in synthetic biology has enabled innovative manufacture of biofuels and the development of biological processes for the manufacture of bulk and fine chemicals. This short review gives

Creation of a Bacterial Cell Controlled by a Chemically Synthesized Genome

The design, synthesis, and assembly of the 1.08–mega–base pair Mycoplasma mycoides JCVI-syn1.0 genome starting from digitized genome sequence information and its transplantation into a M. capricolum recipient cell to create new cells that are controlled only by the synthetic chromosome are reported.

Complete Chemical Synthesis, Assembly, and Cloning of a Mycoplasma genitalium Genome

The methods described here will be generally useful for constructing large DNA molecules from chemically synthesized pieces and also from combinations of natural and synthetic DNA segments.

Precise Manipulation of Chromosomes in Vivo Enables Genome-Wide Codon Replacement

H hierarchical conjugative assembly genome engineering (CAGE) was developed to merge these sets of codon modifications into genomes with 80 precise changes, which demonstrate that these synonymous codon substitutions can be combined into higher-order strains without synthetic lethal effects.

Evolution of Innovation

  • G. Brooke
  • History
    Pharmaceutical Innovation
  • 2003
In 1856, William Henry Perkin was an 18 year-old student at Britain’s Royal College of Chemistry. He was working toward an antimalarial drug that was important to the British Empire as it expanded

Biocatalytic Asymmetric Synthesis of Chiral Amines from Ketones Applied to Sitagliptin Manufacture

An efficient biocatalytic process to replace a recently implemented rhodium-catalyzed asymmetric enamine hydrogenation for the large-scale manufacture of the antidiabetic compound sitagliptin is reported, underscoring the maturation of bioc atalysis to enable efficient, economical, and environmentally benign processes for the manufacture of pharmaceuticals.

New Directions: The Ethics of Synthetic Biology and Emerging Technologies (Presidential Commission for the Study of Bioethical Issues

  • 2010

United Nations Office at Geneva, Disarmament: Think Zone for the Seventh Review Conference, 0FF9CBDC43026888C12577B5004E29E4?OpenDocument