Synthetic Antibodies with a Human Framework That Protect Mice from Lethal Sudan Ebolavirus Challenge

@inproceedings{Chen2014SyntheticAW,
  title={Synthetic Antibodies with a Human Framework That Protect
Mice from Lethal Sudan Ebolavirus Challenge},
  author={Gang Chen and Jayne F. Koellhoffer and Samantha E. Zak and Julia C. Frei and Nina Liu and Hua Long and Wei Ye and Kaajal Nagar and Guohua Pan and Kartik Chandran and John M Dye and Sachdev S. Sidhu and Jonathan R. Lai},
  booktitle={ACS chemical biology},
  year={2014}
}
The ebolaviruses cause severe and rapidly progressing hemorrhagic fever. There are five ebolavirus species; although much is known about Zaire ebolavirus (EBOV) and its neutralization by antibodies, little is known about Sudan ebolavirus (SUDV), which is emerging with increasing frequency. Here we describe monoclonal antibodies containing a human framework that potently inhibit infection by SUDV and protect mice from lethal challenge. The murine antibody 16F6, which binds the SUDV envelope… CONTINUE READING
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