Synthetic Alzheimer amyloid beta/A4 peptides enhance production of complement C3 component by cultured microglial cells.

@article{Haga1993SyntheticAA,
  title={Synthetic Alzheimer amyloid beta/A4 peptides enhance production of complement C3 component by cultured microglial cells.},
  author={Sanae Haga and Kazuhiko Ikeda and Mitsuharu Sato and Tetsuro Ishii},
  journal={Brain research},
  year={1993},
  volume={601 1-2},
  pages={88-94}
}
Primary microglial cultures prepared from newborn mice showed the production and release of the third component of complement (C3). Newly synthesized [35S]methionine-labelled C3 was purified by immunoprecipitation using anti-C3-antibody. C3 was detected by SDS-PAGE and fluoroaraphy of the immunoprecipitated protein from cell lysates as a 195 kDa band, and from the supernatants of cultures as two major bands corresponding to the C3 alpha-chain (125 kDa) and beta-chain (75 kDa), consistent with… CONTINUE READING

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