Synthetic Œstrogenic Agents without the Phenanthrene Nucleus

@article{Dodds1936SyntheticA,
  title={Synthetic {\OE}strogenic Agents without the Phenanthrene Nucleus},
  author={Edward Charles Dodds and W R Lawson},
  journal={Nature},
  year={1936},
  volume={137},
  pages={996-996}
}
THE preparation and physiological properties of synthetic œstrogenic agents were first described in these columns and elsewhere1,2,3. The active compounds described in these publications were derivatives of phenanthrene or 1:2:5:6-dibenzanthracene, and it was noted that at the time of writing no active substances had been discovered which did not contain the phenanthrene nucleus. 
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References

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The Oestrogenic Activity of some Condensed-Ring Compounds in Relation to their other Biological Activities
TLDR
Investigations have brought to light a number of pure synthetic compounds, of known molecular structure, which show this physiological activity, and in some of the compounds studied the activity is of a very high order.
A Synthetic Oestrus-Exciting Compound
TLDR
Ketohydroxy-oestrin is possibly represented by formula (i) in conformity with the hypothesis that the ovarian hormones are formed by degradation of sterols, and in the light of recent developments in the chemistry of the sterols.
Sex Hormones and Cancer-Producing Compounds
TLDR
It seems probable that the formation of a carcinogenic compound from a sterol would involve dehydrogenation to the aromatic state, for reduction of 1:2:5: 6-dibenzanthracene to an octahydro compound results in loss of carcinogenic activity.