Synthesis with improved yield and study on the analgesic effect of 2-hydroxyphencyclidine.

@article{Ahmadi2005SynthesisWI,
  title={Synthesis with improved yield and study on the analgesic effect of 2-hydroxyphencyclidine.},
  author={A. Ahmadi and Mahshid Shafiezadeh and Yaghoob Fathollahi and M. R. Darvich and Ali Mahmoudi and M. Bahmani and B. Rahmati},
  journal={Arzneimittel-Forschung},
  year={2005},
  volume={55 3},
  pages={
          172-6
        }
}
  • A. Ahmadi, Mahshid Shafiezadeh, +4 authors B. Rahmati
  • Published 2005
  • Chemistry, Medicine
  • Arzneimittel-Forschung
  • Phencyclidine (1-(1-phenylcyclohexyl)piperidine, CAS 956-90-1, PCP) has shown analgesic effects. Some of its derivatives have been synthesized and their biological properties were studied. Since a hydroxyl group has been added to the position 2 of the cyclohexane ring of PCP, this compound would be more hydrophilic than PCP. This compound was synthesized using a different and improved method with a higher yield. Its analgesic effect was studied using the tail-flick test on rats and was compared… CONTINUE READING
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