Synthesis, structure and biological activity of nitroxide malonate methanofullerenes.

Abstract

Two nitroxide methanofullerenes was synthesized for the first time, and their structures and biological activities studied. It was shown by X-ray single crystal analysis that the methanofullerene with two nitroxide groups forms a 1 : 2 inclusion complex with chloroform and has a nearly tetrahedral (diamond-like) arrangement of fullerene-fullerene interactions in the crystal. For the first time, it has been found that malonate nitroxide methanofullerene in combination with the known anticancer drug cyclophosphamide (CPA) shows high antitumor activity against leukemia P-388.

Cite this paper

@article{Gubskaya2007SynthesisSA, title={Synthesis, structure and biological activity of nitroxide malonate methanofullerenes.}, author={Valentina P Gubskaya and Lucia Sh Berezhnaya and Aidar T Gubaidullin and Irina I Faingold and Raisa A Kotelnikova and Nina P. Konovalova and Vladimir Igorevich Morozov and Igor A Litvinov and Ildus A Nuretdinov}, journal={Organic & biomolecular chemistry}, year={2007}, volume={5 6}, pages={976-81} }