Synthesis rates of cellular proteins involved in translation and protein folding are strongly altered in response to overproduction of basic fibroblast growth factor by recombinant Escherichia coli.

@article{Rinas1996SynthesisRO,
  title={Synthesis rates of cellular proteins involved in translation and protein folding are strongly altered in response to overproduction of basic fibroblast growth factor by recombinant Escherichia coli.},
  author={Ursula Rinas},
  journal={Biotechnology progress},
  year={1996},
  volume={12 2},
  pages={196-200}
}
The cellular response to temperature-induced production of human basic fibroblast growth (bFGF) factor by recombinant E. coli (bacteriophage lambda PRPL promoter/cI857 repressor expression system) was studied by one- and two-dimensional gel electrophoresis. Temperature shift from 30 to 42 degrees C caused the induction of heat-shock protein synthesis and the repression of synthesis of ribosomal proteins and the protein folding catalyst trigger factor. Compared to control cells, carrying the… CONTINUE READING

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