Synthesis ofO 1.5-(β-D-galactopyranosyl) [DMet2, Hyp5] enkephalin amide, a new highly potent analgesic enkephalin-related glycosyl peptide

@article{Torres1989SynthesisO1,
  title={Synthesis ofO 1.5-(β-D-galactopyranosyl) [DMet2, Hyp5] enkephalin amide, a new highly potent analgesic enkephalin-related glycosyl peptide},
  author={Josep Llu{\'i}s Torres and Isabel Haro and Gregorio Valencia and Francesca Reig and Jos{\'e} Garc{\'i}a-Ant{\'o}n},
  journal={Experientia},
  year={1989},
  volume={45},
  pages={574-576}
}
A new series of O-glycosyl enkephalins has been prepared, following a convergent strategy, with high chemical yields. The galactosyl analogue,O 1.5-(β-D-galactopyranosyl) [DMet2, Hyp5] enkephalin amide proved to be one of the most potent in vivo opioid agonists synthesized up to now.