Synthesis of zwitterionic polymer brushes hybrid silica nanoparticles via controlled polymerization for highly efficient enrichment of glycopeptides.

@article{Huang2014SynthesisOZ,
  title={Synthesis of zwitterionic polymer brushes hybrid silica nanoparticles via controlled polymerization for highly efficient enrichment of glycopeptides.},
  author={Guang Rong Huang and Zhichao Xiong and Hongqiang Qin and Jun Zhu and Zhen Sun and Yi Zhang and Xiaojun Peng and Junjie Ou and Hanfa Zou},
  journal={Analytica chimica acta},
  year={2014},
  volume={809},
  pages={61-8}
}
Zwitterionic hydrophilic interaction chromatography (ZIC-HILIC) materials have been increasingly attractive in glycopeptide enrichment. However, the traditional ZIC-HILIC materials are modified with monolayer zwitterionic molecules on the surface, therefore, the hydrophilicity, detection sensitivity and loading capacity are limited. In this work, we synthesized novel silica nanoparticles with uniform poly(2-(methacryloyloxy)ethyl)dimethyl-(3-sul-fopropyl)ammonium hydroxide (PMSA) brushes… CONTINUE READING