Synthesis of xanthone derivatives based on α-mangostin and their biological evaluation for anti-cancer agents.

@article{Fei2014SynthesisOX,
  title={Synthesis of xanthone derivatives based on α-mangostin and their biological evaluation for anti-cancer agents.},
  author={Xiang Fei and Minmi Jo and B. R. Lee and S B Han and K. S. Lee and Jae-Kyung Jung and Seung-Yong Seo and Young-Shin Kwak},
  journal={Bioorganic & medicinal chemistry letters},
  year={2014},
  volume={24 9},
  pages={
          2062-5
        }
}
A xanthone-derived natural product, α-mangostin is isolated from various parts of the mangosteen, Garcinia mangostana L. (Clusiaceae), a well-known tropical fruit. Novel xanthone derivatives based on α-mangostin were synthesized and evaluated as anti-cancer agents by cytotoxicity activity screening using 5 human cancer cell lines. Some of these analogs had potent to moderate inhibitory activities. The structure-activity relationship studies revealed that phenol groups on C3 and C6 are critical… CONTINUE READING
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