Synthesis of [2-11C]5,5-dimethyl-2,4-oxazolidinedione with and without added dimethyl carbonate as a carrier for studies with positron tomography.

  • J Z Ginos
  • Published 1985 in
    The International journal of applied radiation…

Abstract

Two methods were developed for the synthesis of [2-11C]5,5-dimethyl-2,4-oxazolidinedione ([2-11C]DMO) for use with positron emission tomography to measure regional cerebral tissue pH in vivo in man. In both methods, A and B, [2-11C]dimethyl carbonate (DMC) was prepared from [11C]phosgene and excess of sodium methoxide in methanol containing 2… (More)

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