Synthesis of water-soluble polymeric esters of the antibiotic cefuroxime

Abstract

Water-soluble polymeric esters of the antibiotic cefuroxime were synthesized for the first time by the carbodiimide method using low-molecular-weight poly-(N-2-hydroxypropyl)methacrylamide as a carrier. The synthesized compounds contain 16.6 and 19.5 wt% antibiotic, exhibit antibacterial activity with respect to S. aureus, and are subject to hydrolysis in physiological solution at 37°C (45.4 and 53.2% for 24 and 30 h, respectively).

DOI: 10.1007/s11094-012-0687-2

5 Figures and Tables

Cite this paper

@article{Solovskii2012SynthesisOW, title={Synthesis of water-soluble polymeric esters of the antibiotic cefuroxime}, author={M. V. Solovskii and M. S. Borisenko and M. Yu. Smirnova}, journal={Pharmaceutical Chemistry Journal}, year={2012}, volume={45}, pages={593-596} }