Synthesis of variously coupled conjugates of D-glucose, 1,3,4-oxadiazole, and 1,2,3-triazole for inhibition of glycogen phosphorylase.

@article{Kun2011SynthesisOV,
  title={Synthesis of variously coupled conjugates of D-glucose, 1,3,4-oxadiazole, and 1,2,3-triazole for inhibition of glycogen phosphorylase.},
  author={S{\'a}ndor Kun and Gergo Nagy and Marietta T{\'o}th and Laura Czecze and Albert Nguyen Van Nhien and Tibor Docsa and P{\'a}l Gergely and Maria-Despoina Charavgi and Paraskevi V Skourti and Evangelia D Chrysina and Tam{\'a}s Patonay and L{\'a}szl{\'o} Soms{\'a}k},
  journal={Carbohydrate research},
  year={2011},
  volume={346 12},
  pages={
          1427-38
        }
}
View on PubMed
dea.lib.unideb.hu
49 Citations
Background Citations
5
Methods Citations
2

Tables from this paper

49 Citations

Citation Type

Citation Type

Synthesis of 2-(β-D-glucopyranosylamino)-5-substituted-1,3,4-oxadiazoles for inhibition of glycogen phosphorylase.
New synthesis of 3-(β-D-glucopyranosyl)-5-substituted-1,2,4-triazoles, nanomolar inhibitors of glycogen phosphorylase.
Synthesis of heterocyclic N-(β-D-glucopyranosyl)carboxamides for inhibition of glycogen phosphorylase.
C-Glucopyranosyl-1,2,4-triazol-5-ones: synthesis and inhibition of glycogen phosphorylase.
Synthesis of New C- and N-β-d-Glucopyranosyl Derivatives of Imidazole, 1,2,3-Triazole and Tetrazole, and Their Evaluation as Inhibitors of Glycogen Phosphorylase
TLDR
The aim of the present study was to broaden the structure-activity relationships of C- and N-β-d-glucopyranosyl azole type inhibitors of glycogen phosphorylase and revealed the extreme sensitivity of such type of inhibitors towards the structure of the azole moiety.
C-(β-d-Glucopyranosyl)formamidrazones, formic acid hydrazides and their transformations into 3-(β-d-glucopyranosyl)-5-substituted-1,2,4- triazoles: A synthetic and computational study
Synthesis of substituted 2-(β-D-glucopyranosyl)-benzimidazoles and their evaluation as inhibitors of glycogen phosphorylase.
Synthesis, enzyme kinetics and computational evaluation of N-(β-D-glucopyranosyl) oxadiazolecarboxamides as glycogen phosphorylase inhibitors.
Substituted 1-(isoxazol-3-yl)methyl-1H-1,2,3-triazoles: Synthesis, palladium(II) complexes, and high-turnover catalysis in aqueous media
One pot InCl3-catalyzed synthesis of 1-glycosylmethyl-1H-imidazoles
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 48 REFERENCES
In Search of Glycogen Phosphorylase Inhibitors: 5-Substituted 3-C-Glucopyranosyl-1,2,4-oxadiazoles from β-D-Glucopyranosyl Cyanides upon Cyclization of O-Acylamidoxime Intermediates
Upon treatment with hydroxylamine-, benzyl- and benzoyl-protected β-D-glucopyranosyl cyanides efficiently afforded the corresponding amidoximes. They reacted by O-acylation in the presence of…
Synthesis of N-(β-D-glucopyranosyl)- and N-(2-acetamido-2-deoxy-β-D-glucopyranosyl) amides as inhibitors of glycogen phosphorylase
Synthesis and structure-activity relationships of C-glycosylated oxadiazoles as inhibitors of glycogen phosphorylase.
Synthesis of 1-(D-glucopyranosyl)-1,2,3-triazoles and their evaluation as glycogen phosphorylase inhibitors.
Amide-1,2,3-triazole bioisosterism: the glycogen phosphorylase case
A new, scalable preparation of a glucopyranosylidene-spiro- thiohydantoin: One of the best inhibitors of glycogen phosphorylases
C-(β-D-glucopyranosyl) heterocycles as potential glycogen phosphorylase inhibitors
Per-O-acetylated and -benzoylated β-D-glucopyranosyl cyanides were transformed into the corresponding 5-( β-D-Glucopyranosyl)tetrazoles, 2-( β-D-glucopyranosyl)benzothiazoles, and, via the…
Synthesis of N-(beta-D-glucopyranosyl) monoamides of dicarboxylic acids as potential inhibitors of glycogen phosphorylase.
Synthesis of new glycosyl biuret and urea derivatives as potential glycoenzyme inhibitors.
Synthesis of and a comparative study on the inhibition of muscle and liver glycogen phosphorylases by epimeric pairs of d-gluco- and d-xylopyranosylidene-spiro-(thio)hydantoins and N-(d-glucopyranosyl) amides.
TLDR
The study of epimeric pairs of D-gluco and D-xylo configurated spiro-hydantoins and N-(D-glucopyranosyl)amides corroborated the role of specific hydrogen bridges in binding the inhibitors to the enzyme.
...
1
2
3
4
5
...