Synthesis of variously coupled conjugates of D-glucose, 1,3,4-oxadiazole, and 1,2,3-triazole for inhibition of glycogen phosphorylase.

@article{Kun2011SynthesisOV,
  title={Synthesis of variously coupled conjugates of D-glucose, 1,3,4-oxadiazole, and 1,2,3-triazole for inhibition of glycogen phosphorylase.},
  author={S{\'a}ndor Kun and Gergo Nagy and Marietta T{\'o}th and Laura Czecze and Albert Nguyen Van Nhien and Tibor Docsa and P{\'a}l Gergely and Maria-Despoina Charavgi and Paraskevi V Skourti and Evangelia D Chrysina and Tam{\'a}s Patonay and L{\'a}szl{\'o} Soms{\'a}k},
  journal={Carbohydrate research},
  year={2011},
  volume={346 12},
  pages={
          1427-38
        }
}

Tables from this paper

Synthesis of New C- and N-β-d-Glucopyranosyl Derivatives of Imidazole, 1,2,3-Triazole and Tetrazole, and Their Evaluation as Inhibitors of Glycogen Phosphorylase
TLDR
The aim of the present study was to broaden the structure-activity relationships of C- and N-β-d-glucopyranosyl azole type inhibitors of glycogen phosphorylase and revealed the extreme sensitivity of such type of inhibitors towards the structure of the azole moiety.
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References

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In Search of Glycogen Phosphorylase Inhibitors: 5-Substituted 3-C-Glucopyranosyl-1,2,4-oxadiazoles from β-D-Glucopyranosyl Cyanides upon Cyclization of O-Acylamidoxime Intermediates
Upon treatment with hydroxylamine-, benzyl- and benzoyl-protected β-D-glucopyranosyl cyanides efficiently afforded the corresponding amidoximes. They reacted by O-acylation in the presence of
C-(β-D-glucopyranosyl) heterocycles as potential glycogen phosphorylase inhibitors
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TLDR
The study of epimeric pairs of D-gluco and D-xylo configurated spiro-hydantoins and N-(D-glucopyranosyl)amides corroborated the role of specific hydrogen bridges in binding the inhibitors to the enzyme.
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