Synthesis of indolo[4,3-bc]phenanthridine-6,11(2H,12H)-diones using the schiff base–homophthalic anhydride cyclization reaction

@article{Elsayed2016SynthesisOI,
  title={Synthesis of indolo[4,3-bc]phenanthridine-6,11(2H,12H)-diones using the schiff base–homophthalic anhydride cyclization reaction},
  author={M. S. Elsayed and M. Zeller and M. Cushman},
  journal={Synthetic Communications},
  year={2016},
  volume={46},
  pages={1902 - 1908}
}
ABSTRACT A novel indolophenanthridine ring system has been synthesized via the Schiff base–homophthalic anhydride cyclization followed by thionyl chloride–mediated dehydrogenation and intramolecular Friedel–Crafts acylation. This adds to the array of heterocyclic systems that are available through the cycloaddition reaction of imines with cyclic dicarboxylic acid anhydrides. The cytotoxicities of the indolophenanthridines were investigated in human cancer cell cultures, and the results… Expand

References

SHOWING 1-10 OF 30 REFERENCES
N-Methylimidazole Promotes the Reaction of Homophthalic Anhydride with Imines
...
1
2
3
...