Synthesis of unlabelled and tritium labelled 4‐isothiocyanato‐1‐(1‐phenylcyclohexyl)piperidine (fourphit), tools for the study of the dopamine reuptake complex.

@inproceedings{Linders1992SynthesisOU,
  title={Synthesis of unlabelled and tritium labelled 4‐isothiocyanato‐1‐(1‐phenylcyclohexyl)piperidine (fourphit), tools for the study of the dopamine reuptake complex.},
  author={Joannes Theodorus Maria Linders and Brian R. de Costa and Neile A. Grayson and Kenner C. Rice},
  year={1992}
}
The synthesis of high specific activity tritium labelled 4-isothiocyanato-1-(1-phenylcyclohexyl)piperidine ([3H]fourphit), a probe for the autoradiographic study of the dopamine reuptake complex, is described. An improved, facile synthesis of unlabelled fourphit in high overall yield is also presented. Detailed study of the interaction of unlabelled and tritium labelled fourphit with the dopamine reuptake complex may lead to a better understanding of the actions of cocaine.