Synthesis of thiocarbamide derivatives of β-alanine and aminalon and study of their antiradiation action

Abstract

The present work was based on data for the high radiation-protective activity of the corresponding aminoalkylisothioureas [5, 6], on one hand, and on the fact that the introduction of the carboxylic group into the molecule influences the pharmacological properties of a compound, in particular, lowers its toxicity compared with the base compound [i], on the other hand. It should also be noted that S-(l~carboxy-3-aminopropyl)isothiourea can be considered as a new derivative of am&nalon, a compound h~ving a wide spectrum of biological :: activity [2, 3].

DOI: 10.1007/BF00758567

Cite this paper

@article{Golubev2004SynthesisOT, title={Synthesis of thiocarbamide derivatives of β-alanine and aminalon and study of their antiradiation action}, author={Alexander A Golubev and Yu. V. Shlykov and A. A. Mandrugin and M. N. Semenenko and Vladimir M Fedoseev and G. V. Dontsova and O. N. Rakhmanina and Maia M Konstantinova}, journal={Pharmaceutical Chemistry Journal}, year={2004}, volume={20}, pages={189-190} }