Synthesis of thiadiazole derivatives bearing hydrazone moieties and evaluation of their pharmacological effects on anxiety, depression, and nociception parameters in mice.

@article{Can2012SynthesisOT,
  title={Synthesis of thiadiazole derivatives bearing hydrazone moieties and evaluation of their pharmacological effects on anxiety, depression, and nociception parameters in mice.},
  author={Ozg{\"u}r Devrim Can and Mehlika Dilek Altintop and Umide Demir Ozkay and Umut Irfan Uçel and B{\"u}rge Doğruer and Zafer Asim Kaplancikli},
  journal={Archives of pharmacal research},
  year={2012},
  volume={35 4},
  pages={659-69}
}
Novel thiadiazole derivatives bearing hydrazone moieties were synthesized through the reaction of 2-[(5-methyl-1,3,4-thiadiazol-2-yl)thio)]acetohydrazide with aldehydes/ketones. The chemical structures of the compounds were elucidated by (1)H-NMR, (13)C-NMR, MS-FAB spectral data, and elemental analyses. Behavioral effects of the test compounds in mice were… CONTINUE READING