Synthesis of thebaine and oripavine from codeine and morphine.

@article{Barber1975SynthesisOT,
  title={Synthesis of thebaine and oripavine from codeine and morphine.},
  author={R B Barber and Henry Rapoport},
  journal={Journal of medicinal chemistry},
  year={1975},
  volume={18 11},
  pages={1074-7}
}
A practical synthesis of thebaine and oripavine has been developed from codeine and morphine, respectively. Attempts to use a codeinone intermediate gave poor yields; however, methylation of the potassium salt of codeine to give codeine methyl ether followed by oxidation with gamma-MnO2 gave thebaine in 67% yield from codeine. Similarly, the potassium salt of the di-O-anion of morphine was selectively alkylated to give morphine 6-methyl ether (heterocodeine) in better than 90% yield… CONTINUE READING

From This Paper

Topics from this paper.

Similar Papers

Loading similar papers…