Synthesis of the tricyclic core of labiatin A and australin A.

@article{Clark2011SynthesisOT,
  title={Synthesis of the tricyclic core of labiatin A and australin A.},
  author={J. S. Clark and David Vignard and A. Parkin},
  journal={Organic letters},
  year={2011},
  volume={13 15},
  pages={
          3980-3
        }
}
  • J. S. Clark, David Vignard, A. Parkin
  • Published 2011
  • Chemistry, Medicine
  • Organic letters
  • A concise synthesis of the tricyclic core of the marine diterpene natural products labiatin A and australin A has been accomplished. The key ring-forming transformation is a cascade reaction comprising generation of a copper carbenoid from a diazo ketone, intramolecular reaction of the carbenoid with a cyclic ether, and rearrangement of the resulting free oxonium ylide or its metal-bound equivalent with ring expansion of the original cyclic ether. 
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