Synthesis of the proposed structure of plakevulin A: revised structure of plakevulin A

@article{Saito2004SynthesisOT,
  title={Synthesis of the proposed structure of plakevulin A: revised structure of plakevulin A},
  author={F. Saito and R. Takeuchi and T. Kamino and K. Kuramochi and F. Sugawara and K. Sakaguchi and Susumu Kobayashi and M. Tsuda and J. Kobayashi},
  journal={Tetrahedron Letters},
  year={2004},
  volume={45},
  pages={8069-8071}
}
Abstract A total synthesis of the proposed structure of plakevulin A was accomplished. However, the NMR spectral data of the synthetic plakevulin A were not identical of those of the reported compound. We next converted the synthetic plakevulin A into 1-dihydrountenone A. The 1 H and 13 C NMR spectral data of 1-dihydrountenone A were identical with those of reported plakevulin A except for the peaks derived from levulinic acid. Thus, we repurified sample of the natural product and confirmed… Expand
12 Citations
Synthetic analogues of the manzamenones and plakoridines which inhibit DNA polymerase.
Synthetic and Structure-Activity Relationship Studies on Bioactive Natural Products
  • K. Kuramochi
  • Chemistry, Medicine
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