Synthesis of the marine natural product nalpha-(4-bromopyrrolyl-2-carbonyl)-L-homoarginine, a putative biogenetic precursor of the pyrrole-imidazole alkaloids.

@article{Lindel2000SynthesisOT,
  title={Synthesis of the marine natural product nalpha-(4-bromopyrrolyl-2-carbonyl)-L-homoarginine, a putative biogenetic precursor of the pyrrole-imidazole alkaloids.},
  author={T. Lindel and M. Hochg{\"u}rtel and M. Assmann and M. K{\"o}ck},
  journal={Journal of natural products},
  year={2000},
  volume={63 11},
  pages={
          1566-9
        }
}
Lysine is proposed as an alternative biosynthetic precursor of the pyrrole-imidazole alkaloids frequently found in marine sponges. As a putative key intermediate, the natural product Nalpha-(4-bromopyrrolyl-2-carbonyl)-L-homoarginine (1) from the sponge Agelas wiedenmayeri was synthesized in the solid phase starting from Fmoc/Pmc-protected L-homoarginine and in solution starting from readily available L-lysine methyl ester. 
Organocatalyzed enantioselective aldol reaction of 1H-pyrrole-2,3-diones.
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