Synthesis of the insecticide prothrin and its analogues from biomass-derived 5-(chloromethyl)furfural.


Prothrin, a synthetic pyrethroid insecticide, was synthesized from the biomass-derived platform chemical 5-(chloromethyl)furfural in six steps and overall 65% yield. Two structural analogues of prothrin were also prepared following the same synthetic approach. Preliminary testing of these furan-based pyrethroids against the yellow fever mosquito Aedes… (More)
DOI: 10.1021/jf4045843

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