Synthesis of the glycan moiety of ganglioside HPG-7 with an unusual trimer of sialic acid as the inner sugar residue.

Abstract

The glycan moiety of ganglioside HPG-7, isolated from the sea cucumber (Holothuria pervicax), was synthesized for the first time. The characteristic substructure, a trisialic acid sequence embedded in the glycan, was deliberately constructed by utilizing suitably differentiated sialyl units for various synthetic purposes. Finally, a pentasaccharide was successfully delivered as the hexyl glycoside.

DOI: 10.1039/c1cc13200h

Cite this paper

@article{Iwayama2011SynthesisOT, title={Synthesis of the glycan moiety of ganglioside HPG-7 with an unusual trimer of sialic acid as the inner sugar residue.}, author={Yuki Iwayama and Hiromune Ando and H Tanaka and Hideharu Ishida and Makoto Kiso}, journal={Chemical communications}, year={2011}, volume={47 34}, pages={9726-8} }