Synthesis of the bicyclo[7.3.0]dodecatrienediyne core of the C-1027 chromophore.

@article{Inoue2004SynthesisOT,
  title={Synthesis of the bicyclo[7.3.0]dodecatrienediyne core of the C-1027 chromophore.},
  author={Masayuki Inoue and Suguru Hatano and Masaki Kodama and Takeo Sasaki and Tsukasa Kikuchi and Masahiro Hirama},
  journal={Organic letters},
  year={2004},
  volume={6 21},
  pages={3833-6}
}
[reaction: see text] C-1027, an extremely potent antitumor agent, is composed of chromophore 1 and an apoprotein. Here we report a general and efficient route to the exceedingly reactive bicyclo[7.3.0]dodecatrienediyne core of 1, utilizing selenoxide elimination and epoxide deoxygenation to build the cyclopentadiene and enediyne structures, respectively.