Synthesis of the antimicrobial S-linked glycopeptide, glycocin F.

  title={Synthesis of the antimicrobial S-linked glycopeptide, glycocin F.},
  author={Margaret A Brimble and Pat J B Edwards and Paul W R Harris and Gillian E Norris and Mark L. Patchett and Tom H Wright and Sung-Hyun Yang and Sarah E Carley},
  volume={21 9},
The first total synthesis of glycocin F, a uniquely diglycosylated antimicrobial peptide bearing a rare S-linked N-acetylglucosamine (GlcNAc) moiety in addition to an O-linked GlcNAc, has been accomplished using a native chemical ligation strategy. The synthetic and naturally occurring peptides were compared by HPLC, mass spectrometry, NMR and CD spectroscopy, and their stability towards chymotrypsin digestion and antimicrobial activity were measured. This is the first comprehensive structural… CONTINUE READING
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Carbohydrate Chemistry (Eds

  • D. Horton
  • 1972
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