Synthesis of the Tetrasaccharide Repeating Unit of the β-Kdo-Containing Exopolysaccharide from Burkholderia pseudomallei and B. cepacia Complex.

@article{Laroussarie2015SynthesisOT,
  title={Synthesis of the Tetrasaccharide Repeating Unit of the β-Kdo-Containing Exopolysaccharide from Burkholderia pseudomallei and B. cepacia Complex.},
  author={Ana{\"i}s Laroussarie and Barbara Barycza and Hanitra Andriamboavonjy and Marielle Tamigney Kenfack and Yves Bl{\'e}riot and Charles Gauthier},
  journal={The Journal of organic chemistry},
  year={2015},
  volume={80 20},
  pages={
          10386-96
        }
}
The synthesis of the repeating unit of the immunogenic β-Kdo-containing exopolysaccharide produced by Burkholderia pseudomallei and bacteria of the B. cepacia complex is described. The target tetrasaccharide was synthesized via stereoselective 1,2-cis- and 1,2-trans-galactosylations and β-Kdosylation. A [3 + 1] coupling reaction between a trigalactosyl N-phenyl-2,2,2-trifluoroacetimidate donor and a Kdo acceptor has been successfully achieved for the assembly of the tetrasaccharide skeleton.