Synthesis of the Methyl Ester of Tritium-labeled AK-toxin I, a Host-specific Toxin Produced by Alternaria alternata Japanese Pear Pathotype.

@article{Okada1999SynthesisOT,
  title={Synthesis of the Methyl Ester of Tritium-labeled AK-toxin I, a Host-specific Toxin Produced by Alternaria alternata Japanese Pear Pathotype.},
  author={Maiko Okada and Hisashi Miyagawa and Tomohiro Ueno},
  journal={Bioscience, biotechnology, and biochemistry},
  year={1999},
  volume={63 7},
  pages={1253-60}
}
AK-toxin I, a host-specific toxin to Japanese pear (Pyrus serotina), was synthesized as its methyl ester from three precursor fragments: conjugated diene-carboxylic acid, chiral epoxyalcohol and β-methylphenylalanine. The epoxyalcohol fragment was derived from D-fructose, in which effective homologation of the hemiacetal carbon to alkyne by using dimethyl 1… CONTINUE READING