Synthesis of tetrodotoxin, a classic but still fascinating natural product.


Tetrodotoxin, a toxic principle of puffer fish intoxication, is one of the most famous marine natural products due to its densely functionalized structure and potent toxicity. Despite its small molecular size (MW 319 g mol⁻¹), tetrodotoxin has long been well known as a formidable molecule in natural product synthesis. We have devoted more than twenty years… (More)
DOI: 10.1002/tcr.201200025


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