Synthesis of tetrazole-fused glycosides by a tandem fragmentation-cyclization reaction.

Abstract

The fragmentation of anomeric alkoxyl radicals (ARF) and the subsequent intramolecular cyclization promoted by hypervalent iodine reagents provide an excellent method for the synthesis of tetrazolo-sugars. This new reaction offers additional advantages for the synthesis of these compounds, including the ready availability of the starting materials… (More)
DOI: 10.1021/ol3013638

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