Synthesis of sulfated proteoglycans by bovine glomerular endothelial cells in culture.

@article{Srensson2003SynthesisOS,
  title={Synthesis of sulfated proteoglycans by bovine glomerular endothelial cells in culture.},
  author={Jenny S{\"o}rensson and Anna L Bj{\"o}rnson and Maria Ohlson and Barbara J Ballermann and B{\"o}rje Haraldsson},
  journal={American journal of physiology. Renal physiology},
  year={2003},
  volume={284 2},
  pages={F373-80}
}
It has been suggested that proteinuria is caused by alterations of the charge selectivity of the basement membrane and/or the epithelial cell layer (podocytes). However, recent findings suggest that the endothelial luminal surface coat, consisting of proteoglycans with their connected glycosaminoglycan (GAG) branches and glycoproteins, may contribute to the permselectivity. Therefore, we wanted to investigate the effects on endothelial GAG synthesis during normal and pathological conditions. We… CONTINUE READING