Synthesis of sugar nucleotides by application of phosphoramidites.

  title={Synthesis of sugar nucleotides by application of phosphoramidites.},
  author={Henrik Gold and Pieter van Delft and Nico Meeuwenoord and Jeroen D C Cod{\'e}e and Dmitri V. Filippov and Gerrit Eggink and Herman S Overkleeft and Gijs A. van Der Marel},
  journal={The Journal of organic chemistry},
  volume={73 23},
A new method for the construction of pyrophosphates is reported based on the coupling of a sugar phosphate and a nucleoside phosphoramidite. The in situ formed phosphate-phosphite intermediate was subsequently oxidized with tBuOOH. Three UDP-N-acetylglucosamine derivatives were prepared using this one-pot procedure in good yields.