Synthesis of succinimidyl-(S)-naproxen ester and its application for indirect enantioresolution of penicillamine by reversed-phase high-performance liquid chromatography.

@article{Bhushan2008SynthesisOS,
  title={Synthesis of succinimidyl-(S)-naproxen ester and its application for indirect enantioresolution of penicillamine by reversed-phase high-performance liquid chromatography.},
  author={R. Bhushan and Shivani Tanwar},
  journal={Journal of chromatography. A},
  year={2008},
  volume={1209 1-2},
  pages={
          174-8
        }
}
  • R. Bhushan, Shivani Tanwar
  • Published 2008
  • Chemistry, Medicine
  • Journal of chromatography. A
  • Synthesis of N-succinimidyl-(S)-2-(6-methoxynaphth-2-yl) propionate was carried out by the reaction of (S)-naproxen with N-hydroxysuccinimide in the presence of dicyclohexyl carbodiimide. It was characterized and was used as a chiral derivatizing reagent, under mild conditions, to form diastereomers of dl-penicillamine which were resolved by reversed-phase high-performance liquid chromatography using triethyl ammonium phosphate buffer (pH 4.0, 5mM)-acetonitrile (linear gradient (30min) of… CONTINUE READING
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