Synthesis of substituted acetylenic epoxides followed by indium-catalyzed rearrangement to 2,3,5-trisubstituted furans.

Abstract

Syntheses of various aromatic and aliphatic 2,3,5-trisubstituted furans from acetylenic epoxides are described. These epoxides are directly prepared by nucleophilic ring closure of propargylic alkoxides generated by lithium acetylide addition to α-haloketones. 
DOI: 10.1021/jo2001353

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@article{Kang2011SynthesisOS, title={Synthesis of substituted acetylenic epoxides followed by indium-catalyzed rearrangement to 2,3,5-trisubstituted furans.}, author={Jun Yong Kang and Brian T Connell}, journal={The Journal of organic chemistry}, year={2011}, volume={76 7}, pages={2379-83} }