Synthesis of spiroketals under neutral conditions via a type III ring-rearrangement metathesis strategy.


A conceptually novel approach to spiro- and dispiroketals of various ring-sizes under neutral conditions has been designed which complements the classical thermodynamically driven tactic. Key steps involved the formation of α-alkoxyfurans, their [4+2] or [4+3] cycloaddition reactions and the ring-rearrangement metathesis of the resulting oxabicycles. 
DOI: 10.1039/c1cc14329h
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