Synthesis of some novel 4-arylidene pyrazoles as potential antimicrobial agents

  title={Synthesis of some novel 4-arylidene pyrazoles as potential antimicrobial agents},
  author={Poonam Khloya and M. Pawan Kumar and Arpana Mittal and Neeraj Kumar Aggarwal and Pawan Kumar Sharma},
  booktitle={Organic and medicinal chemistry letters},
BACKGROUND Pyrazole and pyrazolone motifs are well known for their wide range of biological activities such as antimicrobial, anti-inflammatory, and antitumor activities. The incorporation of more than one pharmacophore in a single scaffold is a well known approach for the development of more potent drugs. In the present investigation, a series of differently substituted 4-arylidene pyrazole derivatives bearing pyrazole and pyrazolone pharmacophores in a single scaffold was synthesized… CONTINUE READING

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Synthesis and biological evaluation of some novel thiazolylhydrazinomethylidene ferrocenes as antimicrobial agents

  • N Chandak, P Kumar, C Sharma, KR Aneja, PK Sharma
  • Lett Drug Des Discov
  • 2012
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