Synthesis of some novel 4-arylidene pyrazoles as potential antimicrobial agents

@inproceedings{Khloya2013SynthesisOS,
  title={Synthesis of some novel 4-arylidene pyrazoles as potential antimicrobial agents},
  author={Poonam Khloya and Pawan Kumar and Arpana Mittal and Neeraj Kumar Aggarwal and Pawan Kumar Sharma},
  booktitle={Organic and medicinal chemistry letters},
  year={2013}
}
BACKGROUND Pyrazole and pyrazolone motifs are well known for their wide range of biological activities such as antimicrobial, anti-inflammatory, and antitumor activities. The incorporation of more than one pharmacophore in a single scaffold is a well known approach for the development of more potent drugs. In the present investigation, a series of differently substituted 4-arylidene pyrazole derivatives bearing pyrazole and pyrazolone pharmacophores in a single scaffold was synthesized… CONTINUE READING