Synthesis of sialoclusters appended to calix[4]arene platforms via multiple azide-alkyne cycloaddition. New inhibitors of hemagglutination and cytopathic effect mediated by BK and influenza A viruses.

@article{Marra2008SynthesisOS,
  title={Synthesis of sialoclusters appended to calix[4]arene platforms via multiple azide-alkyne cycloaddition. New inhibitors of hemagglutination and cytopathic effect mediated by BK and influenza A viruses.},
  author={Alberto Marra and Lisa Moni and Daniele Pazzi and Alfredo Corallini and Deborah Bridi and Alessandro Dondoni},
  journal={Organic & biomolecular chemistry},
  year={2008},
  volume={6 8},
  pages={1396-409}
}
Tetra- and octavalent sialoside clusters were prepared in good yields exploiting for the first time the multiple copper-catalyzed cycloaddition of a propargyl thiosialoside with calix[4]arene polyazides. The cycloadducts featured the hydrolytically stable carbon-sulfur bond at the anomeric position and the 1,4-disubstituted triazole ring as the spacer between the sialic acid moieties and the platform. It was demonstrated that these unnatural motifs did not hamper the desired biological activity… CONTINUE READING

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