Synthesis of selective inhibitors of heparan sulfate and chondroitin sulfate proteoglycan biosynthesis.

@article{Mencio2015SynthesisOS,
  title={Synthesis of selective inhibitors of heparan sulfate and chondroitin sulfate proteoglycan biosynthesis.},
  author={Caitlin P Mencio and Dinesh R. Garud and Balagurunathan Kuberan and Mamoru Koketsu},
  journal={Methods in molecular biology},
  year={2015},
  volume={1229},
  pages={69-78}
}
Glycosaminoglycan (GAG) side chains of proteoglycans are involved in a wide variety of developmental and pathophysiological functions. Similar to a gene knockout, the ability to inhibit GAG biosynthesis would allow us to examine the function of endogenous GAG chains. However, ubiquitously and irreversibly knocking out all GAG biosynthesis would cause multiple effects making it difficult to attribute a specific biological role to a specific GAG structure in spatiotemporal manner. Reversible and… CONTINUE READING