Synthesis of selective SRPK-1 inhibitors: novel tricyclic quinoxaline derivatives.


SR protein-specific kinase-1 (SRPK-1) has been identified as a validated target for hepatitis B virus (HBV). A series of novel tricyclic quinoxaline derivatives was designed and synthesised as potential kinase inhibitory antiviral agents and was found to be active and selective for SRPK-1 kinase. Most of these novel compounds have drug-like properties… (More)


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@article{Szkelyhidi2005SynthesisOS, title={Synthesis of selective SRPK-1 inhibitors: novel tricyclic quinoxaline derivatives.}, author={Zsolt Sz{\'e}kelyhidi and J{\'a}nos Pat{\'o} and Frigyes W{\'a}czek and P{\'e}ter B{\'a}nhegyi and B{\'a}lint Hegymegi-Barakonyi and D{\'a}niel Er{\"o}s and Gy{\"o}rgy M{\'e}sz{\'a}ros and Ferenc Holl{\'o}sy and Doris Hafenbradl and Sabine Obert and Bert M. Klebl and Gy{\"o}rgy K{\'e}ri and L{\'a}szlȯ Őrfi}, journal={Bioorganic & medicinal chemistry letters}, year={2005}, volume={15 13}, pages={3241-6} }