Synthesis of secreted and membrane-bound immunoglobulin mu heavy chains is directed by mRNAs that differ at their 3′ ends

@article{Alt1980SynthesisOS,
  title={Synthesis of secreted and membrane-bound immunoglobulin mu heavy chains is directed by mRNAs that differ at their 3′ ends},
  author={F. Alt and A. Bothwell and Michael Knapp and E. Siden and D. Baltimore},
  journal={Cell},
  year={1980},
  volume={20},
  pages={293-301}
}
Abstract The mRNA isolated from B lymphocyte tumor cell lines directs synthesis of two forms of μ heavy chain, one with a molecular weight of 67K and one of 64K. When these cell lines are converted to IgM-secreting cells by fusion with a myeloma cell, the 64K form of μ predominates; thus it is designated μ s (μ-secreted). The 67K form correlates with the presence of surface IgM; thus it is designated μ m (μ-membrane). Cells that make both forms of μ chain have two mRNAs, one of 2.4 kb that… Expand
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