Synthesis of quinoline/naphthalene-containing azaphenothiazines and their potent in vitro antioxidant properties

  title={Synthesis of quinoline/naphthalene-containing azaphenothiazines and their potent in vitro antioxidant properties},
  author={Małgorzata Jeleń and Eugenia I. Bavavea and M. Pappa and Angeliki P. Kourounakis and Beata Morak-Młodawska and Krystian Pluta},
  booktitle={Medicinal Chemistry Research},
New tetracyclic and pentacyclic azaphenothiazines containing one or two quinoline rings instead of benzene rings were obtained in the original reactions of isomeric diquinodithiins, dichlorodiquinolinyl sulfides, and disulfide with aromatic amines. The type of ring fusion in the azaphenothiazine system was concluded from the 1H NMR spectra. The obtained azaphenothiazines were evaluated in vitro for their antioxidant activity on rat hepatic microsomal membranes for protection of non-enzymatic… CONTINUE READING
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