Synthesis of pyridyl disulfide-functionalized nanoparticles for conjugating thiol-containing small molecules, peptides, and proteins.

@article{Vlies2010SynthesisOP,
  title={Synthesis of pyridyl disulfide-functionalized nanoparticles for conjugating thiol-containing small molecules, peptides, and proteins.},
  author={Andr{\'e} J. van der Vlies and C. O'Neil and Urara Hasegawa and Nathan B Hammond and Jeffrey A Hubbell},
  journal={Bioconjugate chemistry},
  year={2010},
  volume={21 4},
  pages={653-62}
}
Previously we reported emulsion polymerization of propylene sulfide with Pluronic F127 as an emulsifier, yielding nanoparticles (NPs) in the 25 nm size range. Immunologically functional NPs were prepared by adding an antigen-Pluronic conjugate to the polymerization mixture ( Reddy , S. T. , et al. ( 2007 ) Nat. Biotechnol. 25, 1159 ). We sought a more flexible scheme for conjugation of antigens and other biomolecules to the NP surfaces that would allow for milder reaction conditions than… CONTINUE READING

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