Synthesis of pyrazoles from 1,3-diols via hydrogen transfer catalysis.

Abstract

1,3-Diols engage in ruthenium-catalyzed hydrogen transfer in the presence of alkyl hydrazines to provide 1,4-disubstituted pyrazoles. Regioselective synthesis of unsymmetrical pyrazoles from β-hydroxy ketones is also described.

DOI: 10.1021/acs.orglett.5b00266

Cite this paper

@article{Schmitt2015SynthesisOP, title={Synthesis of pyrazoles from 1,3-diols via hydrogen transfer catalysis.}, author={Daniel Schmitt and Alexandria P Taylor and Andrew C Flick and Robert E Kyne}, journal={Organic letters}, year={2015}, volume={17 6}, pages={1405-8} }