Synthesis of prostaglandin I2 (prostacyclin) by cultured human and bovine endothelial cells.

Abstract

Cultured endothelial cells derived from human umbilical veins or bovine aorta produce a potent inhibitor of platelet aggregation. The inhibitor is synthesized from sodium arachidonate or or prostaglandin endoperoxides by a microsomal enzyme system. Tranylcypromine, a specific antagonist of prostacyclin synthetase, suppresses production of the inhibitor by… (More)

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@article{Weksler1977SynthesisOP, title={Synthesis of prostaglandin I2 (prostacyclin) by cultured human and bovine endothelial cells.}, author={Babette Weksler and Aaron J. Marcus and E A Jaffe}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={1977}, volume={74 9}, pages={3922-6} }